4.6.0.0. Di­ag­nos­tic Tests for Susp. Hy­popi­tu­itarism

Table 2.2-​​Cri­te­ria for the di­ag­no­sis of di­a­betes

FPG ≥126 mg/​​dL (7.0 mmol/​​L). Fast­ing is defined as no caloric in­take for at least 8 h.*

OR

2-​​h PG ≥200 mg/​​dL (11.1 mmol/​​L) dur­ing OGTT. The test should be per­formed as de­scribed by WHO, us­ing a glu­cose load con­tain­ing the equiv­a­lent of 75 g an­hy­drous glu­cose dis­solved in wa­ter.*

OR

A1C ≥6.5% (48 mmol/​​mol). The test should be per­formed in a lab­o­ra­to­ry us­ing a method that is NGSP cer­tified and stan­dard­ized to the DCCT as­say.*

OR

In a pa­tient with clas­sic symp­toms of hy­per­glycemia or hy­per­glycemic cri­sis, a ran­dom plas­ma glu­cose ≥200 mg/​​dL (11.1 mmol/​​L).

Table 2.5—Cri­te­ria defining pre­di­a­betes*

FPG 100 mg/​​dL (5.6 mmol/​​L) to 125 mg/​​dL (6.9 mmol/​​L) (IFG)

OR

2-​​h PG dur­ing 75-​​g OGTT 140 mg/​​dL (7.8 mmol/​​L) to 199 mg/​​dL (11.0 mmol/​​L) (IGT)

OR

A1C 5.7–6.4% (39–47 mmol/​​mol)


DCCT, Diabetes Control and Complications Trial; FPG, fasting plasma glucose; IFG, impaired fasting glucose; IGT, impaired glucose tolerance; OGTT, oral glucose tolerance test; WHO, World Health Organization; 2-​​h PG, 2-​​h plasma glucose.  

*In conditions associated with increased red blood cell turnover, such as sickle cell disease, pregnancy (second and third trimesters), glucose-6-phosphate dehydrogenase deficiency, hemodialysis, recent blood loss or transfusion, or erythropoietin therapy, only plasma blood glucose criteria should be used to diagnose diabetes
** For all three tests, risk is continuous, extending below the lower limit of the range and becoming disproportionately greater at the higher end of the range.
***In the absence of unequivocal hyperglycemia, diagnosis requires two abnormal test results from the same sample or in two separate test samples.
#See table 2.3 for Criteria for testing for diabetes or prediabetes in asymptomatic adults