Rec­om­men­da­tions

15.4 In­sulin ther­a­py should be ini­ti­at­ed for treat­ment of per­sis­tent hy­per­glycemia start­ing at a thresh­old ≥180 mg/dL (10.0 mmol/‍L). Once in­sulin ther­a­py is start­ed, a tar­get glu­cose range of 140– 180 mg/dL (7.8–10.0 mmol/‍L) is rec­om­mend­ed for the ma­jor­i­ty of crit­i­cal­ly ill pa­tients and noncrit­i­cal­ly ill pa­tients. A

15.5 More strin­gent goals, such as 110–140 mg/dL (6.1–7.8 mmol/‍L), may be ap­pro­pri­ate for se­lect­ed pa­tients, if this can be achieved with­out significant hy­po­glycemia. C