4.4.2.0 Sul­fony­lureas

Sul­fony­lureas are known to cross the pla­cen­ta and have been as­so­ci­at­ed with in­creased neona­tal hy­po­glycemia. Con­cen­tra­tions of gly­buride in um­bil­i­cal cord plas­ma are ap­prox­i­mate­ly 70% of ma­ter­nal lev­els (44,45). Gly­buride was as­so­ci­at­ed with a high­er rate of neona­tal hy­po­glycemia and macro­so­mia than in­sulin or met­formin in a 2015 meta­-anal­y­sis and sys­tematic re­view (46). More re­cent­ly, gly­buride failed to be found non­in­fe­ri­or to in­sulin based on a com­pos­ite out­come of neona­tal hy­po­glycemia, macro­so­mia, and hy­per­biliru­bine­mia. Long-‍term safe­ty data for off­spring are not avail­able (47,48).