3.7.0.0 Di­a­betes With Statin Use

Sev­er­al stud­ies have re­port­ed a mod­est­ly in­creased risk of in­ci­dent di­a­betes with statin use (106,107), which may be lim­it­ed to those with di­a­betes risk fac­tors. An anal­y­sis of one of the ini­tial stud­ies sug­gest­ed that al­though statin use was as­so­ci­at­ed with di­a­betes risk, the car­dio­vas­cu­lar event rate re­duc­tion with statins far out­weighed the risk of in­ci­dent di­a­betes even for pa­tients at high­est risk for di­a­betes (108). The ab­so­lute risk in­crease was small (over 5 years of fol­low-‍up, 1.2% of par­tic­i­pants on place­bo de­vel­oped di­a­betes and 1.5% on ro­su­vas­tatin de­vel­oped di­a­betes) (108). A meta-‍anal­y­sis of 13 ran­dom­ized statin tri­als with 91,140 par­tic­i­pants showed an odds ratio of 1.09 for a new di­ag­no­sis of di­a­betes, so that (on av­er­age) treat­ment of 255 pa­tients with statins for 4 years re­sult­ed in one ad­di­tional case of di­a­betes while si­mul­ta­ne­ous­ly pre­vent­ing 5.4 vas­cu­lar events among those 255 pa­tients (107).