Grow­ing ev­i­dence sug­gests that there is an as­so­ci­a­tion be­tween the ab­sence of noc­tur­nal blood pres­sure dip­ping and the in­ci­dence of ASCVD. A meta-‍anal­y­sis of ran­dom­ized clin­i­cal tri­als found a small benefit of evening ver­sus morn­ing dos­ing of an­ti­hy­per­ten­sive med­i­ca­tions with re­gard to­ blood pres­sure con­trol but had no data on clin­i­cal ef­fects (61). In two sub­group anal­y­ses of a sin­gle sub­se­quent ran­dom­ized con­trolled trial, mov­ing at least one an­ti­hy­per­ten­sive med­i­ca­tion to bed­time significant­ly re­duced car­dio­vas­cu­lar events, but re­sults were based on a small num­ber of events (62).