3.0.0.0 SUR­GI­CAL TREAT­MENT FOR TYPE 1 DI­A­BETES

Pan­creas and Islet Trans­plan­ta­tion

Pan­creas and islet trans­plan­ta­tion nor­mal­izes glu­cose lev­els but re­quires life-‍long im­muno­sup­pres­sion to pre­vent graft re­jec­tion and re­cur­rence of au­toim­mune islet de­struc­tion. Given the po­ten­tial ad­verse ef­fects of im­muno­sup­pres­sive ther­a­py, pan­creas trans­plan­ta­tion should be re­served for pa­tients with type 1 di­a­betes un­der­go­ing si­mul­ta­ne­ous renal trans­plan­ta­tion, fol­low­ing renal trans­plan­ta­tion, or for those with recur­rent ke­toaci­do­sis or se­vere hy­po­glycemia de­spite in­ten­sive glycemic man­age­ment (38).