4.5.0.0 As­sess­ing Efficacy and Safe­ty

Efficacy and safe­ty should be as­sessed at least month­ly for the first 3 months of treat­ment. If a pa­tient’s re­sponse is deemed insufficient (weight loss <5%) after 3 months or if there are significant safe­ty or tol­er­a­bil­i­ty is­sues at any time, the med­i­ca­tion should be discon­tin­ued and al­ter­na­tive med­i­ca­tions or treat­ment ap­proach­es should be con­sid­ered.