3.4.0.0 Id­io­path­ic Type 1 Di­a­betes

Some forms of type 1 di­a­betes have no known eti­olo­gies. These pa­tients have per­ma­nent in­sulinopenia and are prone to DKA, but have no ev­i­dence of β-cell au­toim­mu­ni­ty. Al­though only a mi­nor­i­ty of pa­tients with type 1 di­a­betes fall into this cat­e­go­ry, of those who do, most are of African or Asian an­ces­try. In­di­vid­u­als with this form of di­a­betes suf­fer from episod­ic DKA and ex­hib­it vary­ing de­grees of in­sulin deficien­cy be­tween episodes. This form of di­a­betes is strong­ly in­her­it­ed and is not HLA as­so­ci­at­ed. An ab­so­lute re­quirement for in­sulin re­place­ment ther­a­py in af­fect­ed pa­tients may be in­ter­mit­tent.