5.2.0.0 Preeclampsia and Aspirin
Recommendation
14.12 Women with type 1 or type 2 diabetes should be prescribed low-dose aspirin 60–150 mg/day (usual dose 81 mg/day) from the end of the first trimester until the baby is born in order to lower the risk of preeclampsia. A
Diabetes in pregnancy is associated with an increased risk of preeclampsia (68). Based upon the results of clinical trials, the U.S. Preventive Services Task Force recommends the use of low-dose aspirin (81 mg/day) as a preventive medication after 12 weeks of gestation in women who are at high risk for preeclampsia (69). A cost-benefit analysis has concluded that this approach would reduce morbidity, save lives, and lower health care costs (70).