4.4.0.0 Aspirin Use in People <50 Years of Age
Aspirin is not recommended for those at low risk of ASCVD (such as men and women aged <50 years with diabetes with no other major ASCVD risk factors) as the low benefit is likely to be out-weighed by the risks of bleeding. Clinical judgment should be used for those at intermediate risk (younger patients with one or more risk factors or older patients with no risk factors) until further research is available. Patients’ willingness to undergo long-term aspirin therapy should also be considered (131). Aspirin use in patients aged <21 years is generally contraindicated due to the associated risk of Reye syndrome.